RAF Typhoon FGR4s have conducted a mission with French aircraft in a coordinated attack on an underground arms cache in Syria used by the IS group, as stated by the UK's MoD.
The facility, identified by intelligence, was assessed as storing arms and explosives, the announcement noted, and was positioned in mountains just above the historic site of Palmyra in the heart of Syria.
"Our aircraft utilized Paveway IV guided bombs to hit a series of approach shafts leading to the site... preliminary assessments are that the strike was effective," the MoD said.
There was no evidence of any civilian casualties in the attack on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
IS - also known as ISIS - established jihadist rule over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This strike shows British leadership, and resolve to operate in unison with our allies, to eliminate any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," Britain's Defence Chief John Healey stated.
UK warplanes have performed patrols over Syria to "forestall any attempted comeback" of the group subsequent to its defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank all the members of British forces who took part in this strike for their expertise and their courage," he said. "They were among thousands of UK service members on duty over the festive period. This mission, to take out dangerous terrorists who pose a risk to our security, highlights how British military are prepared to act, throughout the year, keeping Britain secure at home and strong abroad."
Last December, the US military executed what it called a "large-scale strike" against IS targets in the country, following an ambush killed two US troops and a local interpreter in Palmyra.
The United Nations estimates Daesh still has an estimated 5,000 to 7,000 fighters in Syria and Iraq.